PLoS ONE (Jan 2012)

Molecular characterization of chronic lymphocytic leukemia patients with a high number of losses in 13q14.

  • Ana Eugenia Rodríguez,
  • Jose Ángel Hernández,
  • Rocío Benito,
  • Norma C Gutiérrez,
  • Juan Luis García,
  • María Hernández-Sánchez,
  • Alberto Risueño,
  • M Eugenia Sarasquete,
  • Encarna Fermiñán,
  • Rosa Fisac,
  • Alfonso García de Coca,
  • Guillermo Martín-Núñez,
  • Natalia de Las Heras,
  • Isabel Recio,
  • Oliver Gutiérrez,
  • Javier De Las Rivas,
  • Marcos González,
  • Jesús M Hernández-Rivas,
  • Jesús M Hernández-Rivas

DOI
https://doi.org/10.1371/journal.pone.0048485
Journal volume & issue
Vol. 7, no. 11
p. e48485

Abstract

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BackgroundPatients with chronic lymphocytic leukemia and 13q deletion as their only FISH abnormality could have a different outcome depending on the number of cells displaying this aberration. Thus, cases with a high number of 13q- cells (13q-H) had both shorter overall survival and time to first therapy. The goal of the study was to analyze the genetic profile of 13q-H patients.Design and methodsA total of 102 samples were studied, 32 of which served as a validation cohort and five were healthy donors.ResultsChronic lymphocytic leukemia patients with higher percentages of 13q- cells (>80%) showed a different level of gene expression as compared to patients with lower percentages (ConclusionsThis study provides new evidence regarding the heterogeneity of 13q deletion in chronic lymphocytic leukemia patients, showing that apoptosis, proliferation as well as miRNA regulation are involved in cases with higher percentages of 13q- cells.