Nature Communications (Nov 2019)
In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls
- Wei Jiang,
- James R. Birtley,
- Shu-Chen Hung,
- Weiqi Wang,
- Shin-Heng Chiou,
- Claudia Macaubas,
- Birgitte Kornum,
- Lu Tian,
- Huang Huang,
- Lital Adler,
- Grant Weaver,
- Liying Lu,
- Alexandra Ilstad-Minnihan,
- Sriram Somasundaram,
- Sashi Ayyangar,
- Mark M. Davis,
- Lawrence J. Stern,
- Elizabeth D. Mellins
Affiliations
- Wei Jiang
- Department of Pediatrics–Human Gene Therapy, Stanford University School of medicine
- James R. Birtley
- Department of Pathology, University of Massachusetts Medical School
- Shu-Chen Hung
- Department of Pediatrics–Human Gene Therapy, Stanford University School of medicine
- Weiqi Wang
- Human Immune Monitoring Center, Stanford University School of Medicine
- Shin-Heng Chiou
- Institute for Immunity, Transplantation and Infection, Department of Microbiology and Immunology, Stanford University School of Medicine
- Claudia Macaubas
- Department of Pediatrics–Human Gene Therapy, Stanford University School of medicine
- Birgitte Kornum
- Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Rigshospitalet
- Lu Tian
- Department of Biomedical Data Science, Stanford University School of Medicine
- Huang Huang
- Institute for Immunity, Transplantation and Infection, Department of Microbiology and Immunology, Stanford University School of Medicine
- Lital Adler
- Department of Pediatrics–Human Gene Therapy, Stanford University School of medicine
- Grant Weaver
- Department of Pathology, University of Massachusetts Medical School
- Liying Lu
- Department of Pathology, University of Massachusetts Medical School
- Alexandra Ilstad-Minnihan
- Department of Pediatrics–Human Gene Therapy, Stanford University School of medicine
- Sriram Somasundaram
- Department of Pediatrics–Human Gene Therapy, Stanford University School of medicine
- Sashi Ayyangar
- Department of Pediatrics–Human Gene Therapy, Stanford University School of medicine
- Mark M. Davis
- Stanford Immunology, Stanford University School of Medicine
- Lawrence J. Stern
- Department of Pathology, University of Massachusetts Medical School
- Elizabeth D. Mellins
- Department of Pediatrics–Human Gene Therapy, Stanford University School of medicine
- DOI
- https://doi.org/10.1038/s41467-019-13234-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
T cells from narcolepsy patients were recently reported to recognize hypocretin, a wakefulness-promoting neurohormone, suggesting autoimmune origin of the disease. Here the authors show that hypocretin-specific T cells expand both in healthy controls and in narcolepsy patients, and identify preliminary features that may distinguish them.
