An efficient synthesis of furan-3(2<italic toggle="yes">H</italic>)-imine scaffold from alkynones

Abstract

A novel efficient method to generate spiro furan-3(2H)-imine derivatives is established by the reaction between the α,β-unsaturated ketones and aniline derivatives. The reaction involves 1,4- addition of aniline followed by the subsequent intramolecular cyclization mediated by tertiary alcohol to produce the furan-3(2H)-imine. All the synthesized compounds are characterized using nuclear magnetic resonance and high-resolution mass spectrometry (HRMS).

Keywords

• efficient
• synthesis
• furan-3(2H)-imine
• scaffold
• alkynones
• authors