Molecules (Dec 2009)

1-Arylsulfonyl-2-(Pyridylmethylsulfinyl) Benzimidazoles as New Proton Pump Inhibitor Prodrugs

  • Young-moon Cho,
  • Michael Garst,
  • Jai Moo Shin,
  • George Sachs

DOI
https://doi.org/10.3390/molecules14125247
Journal volume & issue
Vol. 14, no. 12
pp. 5247 – 5280

Abstract

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New arylsulfonyl proton pump inhibitor (PPI) prodrug forms were synthesized. These prodrugs provided longer residence time of an effective PPI plasma concentration, resulting in better gastric acid inhibition.

Keywords