Pharmacogenomic markers of glucocorticoid response in the initial phase of remission induction therapy in childhood acute lymphoblastic leukemia

Gasic Vladimir; Zukic Branka; Stankovic Biljana; Janic Dragana; Dokmanovic Lidija; Lazic Jelena; Krstovski Nada; Dolzan Vita; Jazbec Janez; Pavlovic Sonja; Kotur Nikola

doi:10.2478/raon-2018-0034

Radiology and Oncology (Sep 2018)

Pharmacogenomic markers of glucocorticoid response in the initial phase of remission induction therapy in childhood acute lymphoblastic leukemia

Gasic Vladimir,
Zukic Branka,
Stankovic Biljana,
Janic Dragana,
Dokmanovic Lidija,
Lazic Jelena,
Krstovski Nada,
Dolzan Vita,
Jazbec Janez,
Pavlovic Sonja,
Kotur Nikola

Affiliations

Gasic Vladimir: Laboratory for Molecular Biomedicine, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia
Zukic Branka: Laboratory for Molecular Biomedicine, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia
Stankovic Biljana: Laboratory for Molecular Biomedicine, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia
Janic Dragana: Department of Hematology and Oncology, University Children’s Hospital, University of Belgrade, Belgrade, Serbia
Dokmanovic Lidija: Department of Hematology and Oncology, University Children’s Hospital, University of Belgrade, Belgrade, Serbia
Lazic Jelena: Department of Hematology and Oncology, University Children’s Hospital, University of Belgrade, Belgrade, Serbia
Krstovski Nada: Department of Hematology and Oncology, University Children’s Hospital, University of Belgrade, Belgrade, Serbia
Dolzan Vita: Pharmacogenetics Laboratory, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
Jazbec Janez: Department of Oncology and Haematology, University Children’s Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia
Pavlovic Sonja: Laboratory for Molecular Biomedicine, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia
Kotur Nikola: Laboratory for Molecular Biomedicine, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia

DOI: https://doi.org/10.2478/raon-2018-0034
Journal volume & issue: Vol. 52, no. 3
pp. 296 – 306

Abstract

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Response to glucocorticoid (GC) monotherapy in the initial phase of remission induction treatment in childhood acute lymphoblastic leukemia (ALL) represents important biomarker of prognosis and outcome. We aimed to study variants in several pharmacogenes (NR3C1, GSTs and ABCB1) that could contribute to improvement of GC response through personalization of GC therapy.

Published in Radiology and Oncology

ISSN: 1581-3207 (Online)
Publisher: Sciendo
Country of publisher: Slovenia
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://sciendo.com/journal/RAON

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