Minimum Alveolar Concentration of Isoflurane in Rats Chronically Treated with the Synthetic Cannabinoid WIN 55,212-2

Julio Raul Chavez-Monteagudo; José Antonio Ibancovichi; Pedro Sanchez-Aparicio; Sergio Recillas-Morales; Jorge Osorio-Avalos; Marco Antonio De Paz-Campos

doi:10.3390/ani12070853

Animals (Mar 2022)

Minimum Alveolar Concentration of Isoflurane in Rats Chronically Treated with the Synthetic Cannabinoid WIN 55,212-2

Julio Raul Chavez-Monteagudo,
José Antonio Ibancovichi,
Pedro Sanchez-Aparicio,
Sergio Recillas-Morales,
Jorge Osorio-Avalos,
Marco Antonio De Paz-Campos

Affiliations

Julio Raul Chavez-Monteagudo: Department of Veterinary Anesthesia and Analgesia, Facultad de Estudios Superiores Cuautitlán, Hospital de Pequeñas Especies, Universidad Nacional Autónoma de México, Cuautitlan Izcalli 54740, Mexico
José Antonio Ibancovichi: Department of Veterinary Anesthesia and Analgesia, Faculty of Veterinary Medicine, Universidad Autónoma del Estado de México, Toluca 50000, Mexico
Pedro Sanchez-Aparicio: Department of Pharmacology, Faculty of Veterinary Medicine, Universidad Autónoma del Estado de México, Toluca 50000, Mexico
Sergio Recillas-Morales: Department of Pharmacology, Faculty of Veterinary Medicine, Universidad Autónoma del Estado de México, Toluca 50000, Mexico
Jorge Osorio-Avalos: Department of Biostatistics, Faculty of Veterinary Medicine, Universidad Autónoma del Estado de México, Toluca 50000, Mexico
Marco Antonio De Paz-Campos: Department of Pharmacology, Facultad de Estudios Superiores Cuautitlán, Hospital de Pequeñas Especies, Universidad Nacional Autónoma de México, Cuautitlan Izcalli 54740, Mexico

DOI: https://doi.org/10.3390/ani12070853
Journal volume & issue: Vol. 12, no. 7
p. 853

Abstract

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The minimum alveolar concentration MAC of isoflurane was measured in rats chronically treated with WIN 55,212-2. Methods: The MAC of isoflurane was determined in 24 male rats from expiratory samples at time of tail clamping under the following conditions: without treatment MAC(ISO), in rats treated for 21 days with WIN 55,212-2 MAC(ISO + WIN55), and in rats 8 days after stopping treatment with WIN 55,212-2 (MACISO + WIN55 + 8D). Results: The MAC(ISO) was 1.32 ± 0.06. In the MAC(ISO + WIN55) group, the MAC increased to 1.69 ± 0.09 (28%, p-value ≤ (0.0001). Eight days after stopping treatment with WIN55, the MAC did not decrease significantly, 1.67 ± 0.07 (26%, p-value ≤ 0.0001). Conclusions: The administration of WIN 55,212-2 for 21 days increases the MAC of isoflurane in rats. This effect does not disappear 8 days after discontinuation of treatment with the synthetic cannabinoid.

Published in Animals

ISSN: 2076-2615 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Agriculture: Animal culture: Veterinary medicine; Science: Zoology
Website: http://www.mdpi.com/journal/animals/

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