Nature Communications (Jan 2019)
SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target
- Shuofeng Yuan,
- Hin Chu,
- Jasper Fuk-Woo Chan,
- Zi-Wei Ye,
- Lei Wen,
- Bingpeng Yan,
- Pok-Man Lai,
- Kah-Meng Tee,
- Jingjing Huang,
- Dongdong Chen,
- Cun Li,
- Xiaoyu Zhao,
- Dong Yang,
- Man Chun Chiu,
- Cyril Yip,
- Vincent Kwok-Man Poon,
- Chris Chung-Sing Chan,
- Kong-Hung Sze,
- Jie Zhou,
- Ivy Hau-Yee Chan,
- Kin-Hang Kok,
- Kelvin Kai-Wang To,
- Richard Yi-Tsun Kao,
- Johnson Yiu-Nam Lau,
- Dong-Yan Jin,
- Stanley Perlman,
- Kwok-Yung Yuen
Affiliations
- Shuofeng Yuan
- State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Hin Chu
- State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Jasper Fuk-Woo Chan
- State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Zi-Wei Ye
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Lei Wen
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Bingpeng Yan
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Pok-Man Lai
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Kah-Meng Tee
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Jingjing Huang
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Dongdong Chen
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Cun Li
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Xiaoyu Zhao
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Dong Yang
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Man Chun Chiu
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Cyril Yip
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Vincent Kwok-Man Poon
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Chris Chung-Sing Chan
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Kong-Hung Sze
- State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Jie Zhou
- State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Ivy Hau-Yee Chan
- Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Kin-Hang Kok
- State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Kelvin Kai-Wang To
- State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Richard Yi-Tsun Kao
- State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Johnson Yiu-Nam Lau
- Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Dong-Yan Jin
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Stanley Perlman
- Department of Microbiology and Immunology, University of Iowa
- Kwok-Yung Yuen
- State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- DOI
- https://doi.org/10.1038/s41467-018-08015-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Viruses rely on host cell metabolism for replication, making these pathways potential therapeutic targets. Here, the authors show that AM580, a retinoid derivative and RAR-α agonist, affects replication of several RNA viruses by interfering with the activity of SREBP.
