Structures of β1-adrenergic receptor in complex with Gs and ligands of different efficacies

Minfei Su; Navid Paknejad; Lan Zhu; Jinan Wang; Hung Nguyen Do; Yinglong Miao; Wei Liu; Richard K. Hite; Xin-Yun Huang

doi:10.1038/s41467-022-31823-1

Nature Communications (Jul 2022)

Structures of β1-adrenergic receptor in complex with Gs and ligands of different efficacies

Minfei Su,
Navid Paknejad,
Lan Zhu,
Jinan Wang,
Hung Nguyen Do,
Yinglong Miao,
Wei Liu,
Richard K. Hite,
Xin-Yun Huang

Affiliations

Minfei Su: Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University
Navid Paknejad: Structural Biology Program, Memorial Sloan Kettering Cancer Center
Lan Zhu: Cancer Center and Department of Pharmacology and Toxicology, Medical College of Wisconsin
Jinan Wang: Center for Computational Biology and Department of Molecular Biosciences, University of Kansas
Hung Nguyen Do: Center for Computational Biology and Department of Molecular Biosciences, University of Kansas
Yinglong Miao: Center for Computational Biology and Department of Molecular Biosciences, University of Kansas
Wei Liu: Cancer Center and Department of Pharmacology and Toxicology, Medical College of Wisconsin
Richard K. Hite: Structural Biology Program, Memorial Sloan Kettering Cancer Center
Xin-Yun Huang: Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University

DOI: https://doi.org/10.1038/s41467-022-31823-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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Su et al. report cryo-EM structures of β1-adrenergic receptor, Gs and ligands of different efficacies. These complexes have similar overall architecture, but with local conformational differences and different stabilities.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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