Nature Communications (Sep 2022)
Combined IgE neutralization and Bifidobacterium longum supplementation reduces the allergic response in models of food allergy
- Seong Beom An,
- Bo-Gie Yang,
- Gyeonghui Jang,
- Do-Yeon Kim,
- Jiyoung Kim,
- Sung-Man Oh,
- Nahyun Oh,
- Sanghee Lee,
- Ji-Yeong Moon,
- Jeong-Ah Kim,
- Ji-Hyun Kim,
- Yoo-Jeong Song,
- Hye-Won Hyun,
- Jisoo Kim,
- Kyungwha Lee,
- Dajeong Lee,
- Min-Jung Kwak,
- Byung Kwon Kim,
- Young-Kyu Park,
- Chun-Pyo Hong,
- Jung Hwan Kim,
- Hye Seong Lim,
- Min Sook Ryu,
- Hyun-Tak Jin,
- Seung-Woo Lee,
- Yoon-Seok Chang,
- Hae-Sim Park,
- Young Chul Sung,
- Myoung Ho Jang
Affiliations
- Seong Beom An
- Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH)
- Bo-Gie Yang
- Research Institute, GI Innovation Inc., Songpa
- Gyeonghui Jang
- Research Institute, GI Innovation Inc., Songpa
- Do-Yeon Kim
- Research Institute, GI Innovation Inc., Songpa
- Jiyoung Kim
- Research Institute, GI Innovation Inc., Songpa
- Sung-Man Oh
- Research Institute, GI Innovation Inc., Songpa
- Nahyun Oh
- Research Institute, GI Innovation Inc., Songpa
- Sanghee Lee
- Research Institute, GI Innovation Inc., Songpa
- Ji-Yeong Moon
- Department of Allergy and Clinical Immunology, Ajou University School of Medicine
- Jeong-Ah Kim
- Research Institute, GI Innovation Inc., Songpa
- Ji-Hyun Kim
- Research Institute, GI Innovation Inc., Songpa
- Yoo-Jeong Song
- Research Institute, GI Innovation Inc., Songpa
- Hye-Won Hyun
- Research Institute, GI Innovation Inc., Songpa
- Jisoo Kim
- Research Institute, GI Innovation Inc., Songpa
- Kyungwha Lee
- Research Institute, GI Innovation Inc., Songpa
- Dajeong Lee
- Research Institute, GI Biome Inc.
- Min-Jung Kwak
- Research Institute, GI Biome Inc.
- Byung Kwon Kim
- Research Institute, GI Biome Inc.
- Young-Kyu Park
- Research Institute, GI Biome Inc.
- Chun-Pyo Hong
- Research Institute, GI Innovation Inc., Songpa
- Jung Hwan Kim
- Research Institute, ProGen Inc.
- Hye Seong Lim
- Research Institute, ProGen Inc.
- Min Sook Ryu
- Department of Allergy and Clinical Immunology, Ajou University School of Medicine
- Hyun-Tak Jin
- Research Institute, ProGen Inc.
- Seung-Woo Lee
- Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH)
- Yoon-Seok Chang
- Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine
- Hae-Sim Park
- Department of Allergy and Clinical Immunology, Ajou University School of Medicine
- Young Chul Sung
- Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH)
- Myoung Ho Jang
- Research Institute, GI Innovation Inc., Songpa
- DOI
- https://doi.org/10.1038/s41467-022-33176-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
IgE is a critical component of the allergic response and therapeutic targeting can alleviate symptomology. Here the authors propose the combined use of Bifidobacterium longum and a FcεRIα extracellular domain linked to a IgD/IgG4 hybrid Fc domain fusion protein called IgETRAP and show reduction of mast cell and IgE levels in models of food allergy.
