Effects of Injectable Propofol Emulsion on Singlet Oxygen Released From Activated Human Neutrophils and That Chemically Generated

Chika Senda; Yoko Nishinaka; Toshiyuki Arai; Hajime Segawa; Hiroko Mori; Mitsuru Nonogawa; Nobuyuki Endo; Takashi Miyoshi; Kouhei Yamashita; Masataka Sasada

Journal of Pharmacological Sciences (Jan 2008)

Effects of Injectable Propofol Emulsion on Singlet Oxygen Released From Activated Human Neutrophils and That Chemically Generated

Chika Senda,
Yoko Nishinaka,
Toshiyuki Arai,
Hajime Segawa,
Hiroko Mori,
Mitsuru Nonogawa,
Nobuyuki Endo,
Takashi Miyoshi,
Kouhei Yamashita,
Masataka Sasada

Affiliations

Chika Senda: School of Health Science, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan
Yoko Nishinaka: School of Health Science, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan
Toshiyuki Arai: Department of Anesthesia, Kyoto 606-8507, Japan; Corresponding author. [email protected]
Hajime Segawa: Department of Anesthesia, Kyoto 606-8507, Japan
Hiroko Mori: Department of Anesthesia, Higashiyama Takeda Hospital, Kyoto 605-0932, Japan
Mitsuru Nonogawa: Institute of Advanced Energy, Kyoto University, Uji 611-0011, Japan
Nobuyuki Endo: Wakasa Wan Energy Research Center, Tsuruga 914-0129, Japan
Takashi Miyoshi: Department of Hematology and Oncology, Kyoto University Hospital, Kyoto 606-8507, Japan
Kouhei Yamashita: Department of Hematology and Oncology, Kyoto University Hospital, Kyoto 606-8507, Japan
Masataka Sasada: School of Health Science, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan

Journal volume & issue: Vol. 107, no. 4
pp. 460 – 464

Abstract

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Effects of an injectable emulsion of propofol and its emulsifier on singlet oxygen (1O2) were examined. 1O2 released from activated human neutrophils was detected by chemiluminescence, and chemically generated 1O2 was detected by electron paramagnetic resonance (EPR). Both the propofol emulsion and the emulsifier suppressed 1O2 release from neutrophils. However, the emulsifier did not quench chemically generated 1O2, while the propofol emulsion quenched it. These results indicated that the emulsifier did not scavenge 1O2 released from neutrophils but inhibited 1O2 generation. The suppressive effects of propofol emulsion on 1O2 release from neutrophils consist of 1O2 scavenging and inhibition of 1O2 generation. Keywords:: propofol emulsion, emulsifier, singlet oxygen

Published in Journal of Pharmacological Sciences

ISSN: 1347-8613 (Print)
Publisher: Elsevier
Country of publisher: Japan
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://www.journals.elsevier.com/journal-of-pharmacological-sciences

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