Cripto favours chondrocyte hypertrophy via TGF-beta SMAD1/5 signaling in experimental osteoarthritis

• Gonzalo Sanchez-Duffhues,
• Amaya Garcia de Vinuesa Antuñano,
• Esmeralda Blaney-Davidson,
• Arjan van Caam,
• Kirsten Lodder,
• Yolande Ramos,
• Margreet Kloppenburg,
• Ingrid Meulenbelt,
• Peter van der Kraan,
• Marie-José Goumans,
• Peter ten Dijke

Affiliations

Gonzalo Sanchez-Duffhues

Leiden University Medical Center, Cell and Chemical Biology, Leiden, Netherlands; Corresponding author.

Amaya Garcia de Vinuesa Antuñano

Leiden University Medical Center, Cell and Chemical Biology, Leiden, Netherlands

Esmeralda Blaney-Davidson

Radboud University- Nijmegen Medical Centre, Experimental Rheumatology & Advanced Therapeutics, Nijmegen, Netherlands

Arjan van Caam

Radboud University- Nijmegen Medical Centre, Experimental Rheumatology & Advanced Therapeutics, Nijmegen, Netherlands

Kirsten Lodder

Leiden University Medical Center, Cell and Chemical Biology, Leiden, Netherlands

Yolande Ramos

Leiden University Medical Center, Department of Biomedical Data Sciences, Leiden, Netherlands

Margreet Kloppenburg

Leiden University Medical Center, Department of Biomedical Data Sciences, Leiden, Netherlands

Ingrid Meulenbelt

Leiden University Medical Center, Department of Biomedical Data Sciences, Leiden, Netherlands

Peter van der Kraan

Radboud University- Nijmegen Medical Centre, Experimental Rheumatology & Advanced Therapeutics, Nijmegen, Netherlands

Marie-José Goumans

Leiden University Medical Center, Cell and Chemical Biology, Leiden, Netherlands

Peter ten Dijke

Leiden University Medical Center, Cell and Chemical Biology, Leiden, Netherlands