Trypsinogen activation peptide induces HMGB1 release from rat pancreatic acinar cells

Abstract

The development of acute pancreatitis (AP) is associated with intracellular events in pancreatic cells, as well as with early and late inflammatory responses; however, their underlying mechanisms remain unclear. This study investigated trypsinogen activation peptide (TAP)-induced release of high mobility group box-l (HMGB1) from pancreatic acinar cells and how ethyl pyruvate (EP) affects this release.

Keywords

• Pancreatic acinar cell
• Trypsinogen activation peptide
• High mobility group box-1
• Ethyl pyruvate
• Rat