Nature Communications (Jul 2016)

Essential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosis

  • Midori Shimada,
  • Takahiro Goshima,
  • Hiromi Matsuo,
  • Yoshikazu Johmura,
  • Mayumi Haruta,
  • Kazuhiro Murata,
  • Hiromitsu Tanaka,
  • Masahito Ikawa,
  • Keiko Nakanishi,
  • Makoto Nakanishi

DOI
https://doi.org/10.1038/ncomms12059
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 11

Abstract

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Aurora B activation at the centromere is critical for faithful chromosome segregation in mammals. Here the authors show that Aurora B-mediated phosphorylation of histone H2AX at serine 121 is essential for Aurora B auto-activation circuitry at centromeres, ensuring proper chromosome segregation.