Novel adjuvant nano-vaccine induced immune response against Acinetobacter baumannii

Abstract

Key points Novel CPG-DNA adjuvant nano-vaccine against A. baumannii was constructed. The bacterial load in the serum of mice infected with pDNA-CPG C274/ CSNP post-challenge was substantially lower than in control groups. In BALB/c mice, pDNA-CPG C274/ CSNP induced specific total-IgG antibodies, Th1 cellular immunity, the TLR-9 pathway, and protection against a fatal intraperitoneal A. baumannii challenge.

Keywords

• A. baumannii
• CPG-adjuvant vaccine
• Polymeric nanoparticles
• Chitosan