Structural and functional analysis of mRNA export regulation by the nuclear pore complex

Daniel H. Lin; Ana R. Correia; Sarah W. Cai; Ferdinand M. Huber; Claudia A. Jette; André Hoelz

doi:10.1038/s41467-018-04459-3

Nature Communications (Jun 2018)

Structural and functional analysis of mRNA export regulation by the nuclear pore complex

Daniel H. Lin,
Ana R. Correia,
Sarah W. Cai,
Ferdinand M. Huber,
Claudia A. Jette,
André Hoelz

Affiliations

Daniel H. Lin: Division of Chemistry and Chemical Engineering, California Institute of Technology
Ana R. Correia: Division of Chemistry and Chemical Engineering, California Institute of Technology
Sarah W. Cai: Division of Chemistry and Chemical Engineering, California Institute of Technology
Ferdinand M. Huber: Division of Chemistry and Chemical Engineering, California Institute of Technology
Claudia A. Jette: Division of Chemistry and Chemical Engineering, California Institute of Technology
André Hoelz: Division of Chemistry and Chemical Engineering, California Institute of Technology

DOI: https://doi.org/10.1038/s41467-018-04459-3
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 19

Abstract

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The export of mRNA to the cytosol depends on the nuclear pore complex (NPC) and the activation of the helicase DDX19, but their interplay in humans remains poorly understood. Here, the authors present a structural and functional analysis of DDX19 activation, revealing how the human NPC regulates mRNA export.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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