Antitumor potentials of onco-microbial in Chinese patients with pancreatic cancer

Yong-Chao Gao; Ding-Ding Zhou; Ye-Bin Lu; Li Yang; Xue-Jun Gong; Man-Yun Chen; Shuai Liang; Wei-Hua Huang; Wei Zhang

Heliyon (Dec 2024)

Antitumor potentials of onco-microbial in Chinese patients with pancreatic cancer

Yong-Chao Gao,
Ding-Ding Zhou,
Ye-Bin Lu,
Li Yang,
Xue-Jun Gong,
Man-Yun Chen,
Shuai Liang,
Wei-Hua Huang,
Wei Zhang

Affiliations

Yong-Chao Gao: Engineering Research Center of Applied Technology of Pharmacogenomics (Ministry of Education, China), Hunan Key Laboratory of Pharmacomicrobiomics, Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410078, China
Ding-Ding Zhou: Engineering Research Center of Applied Technology of Pharmacogenomics (Ministry of Education, China), Hunan Key Laboratory of Pharmacomicrobiomics, Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410078, China
Ye-Bin Lu: Department of General Surgery, Xiangya Hospital, Central South University, Changsha, 41008, China
Li Yang: Department of Pharmacy, Hunan Provincial People's Hospital, the First Affiliated Hospital of Hunan Normal University, No.61 Western Jiefang Road, Changsha, Hunan, China
Xue-Jun Gong: Department of General Surgery, Xiangya Hospital, Central South University, Changsha, 41008, China
Man-Yun Chen: Engineering Research Center of Applied Technology of Pharmacogenomics (Ministry of Education, China), Hunan Key Laboratory of Pharmacomicrobiomics, Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410078, China
Shuai Liang: Department of General Surgery, Xiangya Hospital, Central South University, Changsha, 41008, China; Corresponding author. Department of General Surgery, Xiangya Hospital, Central South University, Changsha 41008, China.
Wei-Hua Huang: Engineering Research Center of Applied Technology of Pharmacogenomics (Ministry of Education, China), Hunan Key Laboratory of Pharmacomicrobiomics, Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410078, China; Corresponding author. Hunan Key Laboratory of Pharmacomicrobiomics, Engineering Research Center of Applied Technology of Pharmacogenomics (Ministry of Education), Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410078, China.
Wei Zhang: Engineering Research Center of Applied Technology of Pharmacogenomics (Ministry of Education, China), Hunan Key Laboratory of Pharmacomicrobiomics, Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410078, China; Corresponding author. Hunan Key Laboratory of Pharmacomicrobiomics, Engineering Research Center of Applied Technology of Pharmacogenomics (Ministry of Education), Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410078, China.

Journal volume & issue: Vol. 10, no. 24
p. e40890

Abstract

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Recent studies have revealed that intratumoral microbiota is implicated in pancreatic cancer (PC), yet the spectra of intratumoral microbiota and their relationship with PC in Chinese patients remained to be clarified. In this study, tumor and paired paracancerous tissue from 53 patients were profiled by bacterial 16S rRNA gene sequencing. Both α- and β-diversity displayed significant differences between tumors and adjacent tissues, with higher diversity in tumors. Three bacteria phyla (Proteobacteria, Firmicutes, and Actinobacteria) were prevalent in both cancers and adjacent normal tissues. A high prevalence of Pseudomonas has been identified in the PC tumor microenvironment and was associated with prolonged overall survival. Furthermore, the results of in vitro experiments suggested that Pseudomonas fluorescens (P. fluorescens) could inhibit the proliferation and induce apoptosis of pancreatic cancer cells. These findings revealed distinctive microbial features of the PC tumors and normal tissues in Chinese populations and exhibited the antitumor potential of P. fluorescens in PC.

Published in Heliyon

ISSN: 2405-8440 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Science (General); Social Sciences: Social sciences (General)
Website: https://www.cell.com/heliyon/home

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