Nature Communications (Jun 2022)
Detection of SARS-CoV-2 intra-host recombination during superinfection with Alpha and Epsilon variants in New York City
- Joel O. Wertheim,
- Jade C. Wang,
- Mindy Leelawong,
- Darren P. Martin,
- Jennifer L. Havens,
- Moinuddin A. Chowdhury,
- Jonathan E. Pekar,
- Helly Amin,
- Anthony Arroyo,
- Gordon A. Awandare,
- Hoi Yan Chow,
- Edimarlyn Gonzalez,
- Elizabeth Luoma,
- Collins M. Morang’a,
- Anton Nekrutenko,
- Stephen D. Shank,
- Stefan Silver,
- Peter K. Quashie,
- Jennifer L. Rakeman,
- Victoria Ruiz,
- Lucia V. Torian,
- Tetyana I. Vasylyeva,
- Sergei L. Kosakovsky Pond,
- Scott Hughes
Affiliations
- Joel O. Wertheim
- Department of Medicine, University of California San Diego
- Jade C. Wang
- New York City Public Health Laboratory, New York City Department of Health and Mental Hygiene
- Mindy Leelawong
- New York City Public Health Laboratory, New York City Department of Health and Mental Hygiene
- Darren P. Martin
- Institute of Infectious Diseases and Molecular Medicine, University of Cape Town
- Jennifer L. Havens
- Bioinformatics and Systems Biology Graduate Program, University of California San Diego
- Moinuddin A. Chowdhury
- New York City Public Health Laboratory, New York City Department of Health and Mental Hygiene
- Jonathan E. Pekar
- Bioinformatics and Systems Biology Graduate Program, University of California San Diego
- Helly Amin
- New York City Public Health Laboratory, New York City Department of Health and Mental Hygiene
- Anthony Arroyo
- New York City Public Health Laboratory, New York City Department of Health and Mental Hygiene
- Gordon A. Awandare
- West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana
- Hoi Yan Chow
- New York City Public Health Laboratory, New York City Department of Health and Mental Hygiene
- Edimarlyn Gonzalez
- New York City Public Health Laboratory, New York City Department of Health and Mental Hygiene
- Elizabeth Luoma
- Bureau of the Communicable Diseases, New York City Department of Health and Mental Hygiene
- Collins M. Morang’a
- West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana
- Anton Nekrutenko
- Department of Biochemistry and Molecular Biology, The Pennsylvania State University
- Stephen D. Shank
- Department of Biology, Temple University
- Stefan Silver
- New York City Public Health Laboratory, New York City Department of Health and Mental Hygiene
- Peter K. Quashie
- West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana
- Jennifer L. Rakeman
- New York City Public Health Laboratory, New York City Department of Health and Mental Hygiene
- Victoria Ruiz
- New York City Public Health Laboratory, New York City Department of Health and Mental Hygiene
- Lucia V. Torian
- New York City Public Health Laboratory, New York City Department of Health and Mental Hygiene
- Tetyana I. Vasylyeva
- Department of Medicine, University of California San Diego
- Sergei L. Kosakovsky Pond
- Department of Biology, Temple University
- Scott Hughes
- New York City Public Health Laboratory, New York City Department of Health and Mental Hygiene
- DOI
- https://doi.org/10.1038/s41467-022-31247-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
Here, the authors characterize a case of SARS-CoV-2 superinfection with Alpha and Epsilon variants, in which, via full genome sequencing analyses, they identify recombinant haplotypes in the spike, nucleocapsid, and ORF 8 coding regions, suggesting recombination could play a role in SARS-CoV-2 genetic diversity.
