AGE-RELATED DYNAMICS OF HEMOGRAM AND IMMUNE PROFILE IN CHILDREN AT DIFFERENT AGES

Abstract

Abstract. General parameters of blood cells and immunity (including minor lymphocyte subpopulations) were determined in 196 healthy children from Chita City and 5 districts of the Chita Region, preceded by preselection of the subjects, using multi-step health evaluation schedules.When analyzing data on red blood cells, erythrocyte color index was found to become stable by the age of 3 years, followed by stabilization of blood hemoglobin content by the age of 7 years. RBC indices become stable at later ages..Basic leukocyte populations reach stability by 11 years, except for the numbers of neutrophilic granulocytes (by 15 years). All the T-cell subpopulations including the minor ones (NKT, HLA-DR+) continue to mature until 18 years, except for T-helpers, that become constant in their numbers after 7 years. Serum IgG levels stabilize by the age of 7 years; IgA and IgM amounts – by 18 years. (Med. Immunol., 2011, vol. 13, N 2-3, pp 261-266)

Keywords

• immunity
• hemogram
• age dynamics
• minor subpopulations
• flow cytometry