Сахарный диабет (Dec 2013)

Novel approach to pathophysiology of type 2 diabetes mellitus

  • Emil' Kopeevich Mukhamedzhanov,
  • Oleg Viktorovich Esyrev

DOI
https://doi.org/10.14341/DM2013449-51
Journal volume & issue
Vol. 16, no. 4
pp. 49 – 51

Abstract

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In this paper, we present a model of interplay between protein, lipid and carbohydrate metabolic pathways with regard to the carbon chain transporting systems, as well as generation and consumption of energy. This model elucidates the role of protein metabolism in the impairment of glucose tolerance during the absorption period. We also discuss the effects on energy homeostasis exercised by cytokines via mTOR pathway (the key factor of insulin signalling) considering the phenomenon of insulin resistance.

Keywords