eJHaem (Aug 2021)

In‐hospital mortality in SARS‐CoV‐2 stratified by hemoglobin levels: A retrospective study

  • Mohammed Al‐Jarallah,
  • Rajesh Rajan,
  • Ahmad Al Saber,
  • Jiazhu Pan,
  • Ahmad T. Al‐Sultan,
  • Hassan Abdelnaby,
  • Moudhi Alroomi,
  • Raja Dashti,
  • Wael Aboelhassan,
  • Farah Almutairi,
  • Mohammed Abdullah,
  • Naser Alotaibi,
  • Mohammad Al Saleh,
  • Noor AlNasrallah,
  • Bader Al‐Bader,
  • Haya Malhas,
  • Maryam Ramadhan,
  • Mahdy Hamza,
  • Kobalava D. Zhanna

DOI
https://doi.org/10.1002/jha2.195
Journal volume & issue
Vol. 2, no. 3
pp. 335 – 339

Abstract

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Abstract This study is to estimate in‐hospital mortality in severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) patients stratified by hemoglobin (Hb) level. Patients were stratified according to hemoglobin level into two groups, that is, Hb 100 g/L. A total of 6931 patients were included. Of these, 6377 (92%) patients had hemoglobin levels >100 g/L. The mean age was 44 ± 17 years, and 66% of the patients were males. The median length of overall hospital stay was 13 days [2; 31]. The remaining 554 (8%) patients had a hemoglobin level 100 g/L (52, 0.82%). Risk factors associated with increased mortality were determined by multivariate analysis. The Kaplan‐Meier survival analysis showed hemoglobin as a predictor of mortality. Cox proportional hazards regression coefficients for hemoglobin for the HB ≤ 100 category of hemoglobin were significant, B = 2.79, SE = 0.17, and HR = 16.34, p < 0.001. Multivariate logistic regression showed Hb < 100 g/L had a higher cumulative all‐cause in‐hospital mortality (22.4% vs. 0.8%; adjusted odds ratio [aOR], 0.33; 95% [CI]: [0.20–0.55]; p < 0.001). In this study, hemoglobin levels <100 g/L were found to be an independent predictor of in‐hospital mortality.

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