Cytokine status in patients with chronic obstructive pulmonary disease and its relationships with bone tissue function

Abstract

Aim. To study cytokine status in patients with chronic obstructive pulmonary disease (COPD) and its interrelations with bone metabolism. Material and methods. The levels of pro-inflammatory and anti-inflammatory cytokines, bone metabolism markers in the blood were evaluated in 80 patients with COPD. Results. Changes in cytokine status in COPD patients was established: an increase in pro-inflammatory cytokines and change in anti-inflammatory cytokines. There was hyperproduction of serum proinflammatroy cytokines (IL-lp, IL-6, 1L-8, TNF-a) dependent on FEV1. IL-10 was markedly elevated (p 0.05) in patients with COPD. A correlation analysis showed a positive correlation between IL-10, IL-4 and FEV1; IL-10, IL-4 and osteocalcine (bone formation marker), pro-inflammatory cytokines (IL-ip, IL-6 and TNFa) and Crosslaps (bone resorption marker). A negative correlation was discovered between IL-lp, TNFa and body mass index; IL-8 and osteocalcine. Conclusion. A significant role of cytokine-mediated mechanism in pathogenesis of pulmonogenic osteopenia.

Keywords

• cytokines
• chronic obstructive pulmonary disease
• osteoporosis
• bone metabolism