Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry (Dec 2019)
Multi-component Reaction Synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitriles Using Ultrasonication and Dmap as Catalyst
Abstract
4-(Dimethylamino)pyridine was found to be the homogenous and efficient catalyst for one-pot, multi-component reactions between hydrazine monohydrate, ethyl cyanoacetate, ketone, and malononitrile for the synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitrile derivatives using ultrasonication at room temperature in ethanol solution within 35-50 min with yields of over 90%. This procedure offers various remarkable features such as short reaction times, clean reaction condition, excellent yields, and easy work-up methods.
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