Frontiers in Immunology (Jun 2023)
Myeloid-derived suppressor cells and pulmonary hypertension
- Hui Zhang,
- Hui Zhang,
- Hui Zhang,
- Hui Zhang,
- Hui Zhang,
- Qi-Wei Li,
- Qi-Wei Li,
- Qi-Wei Li,
- Qi-Wei Li,
- Qi-Wei Li,
- Yuan-Yuan Li,
- Yuan-Yuan Li,
- Yuan-Yuan Li,
- Yuan-Yuan Li,
- Xue Tang,
- Xue Tang,
- Xue Tang,
- Xue Tang,
- Ling Gu,
- Ling Gu,
- Ling Gu,
- Ling Gu,
- Han-Min Liu,
- Han-Min Liu,
- Han-Min Liu,
- Han-Min Liu,
- Han-Min Liu
Affiliations
- Hui Zhang
- Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China
- Hui Zhang
- The Fifth People’s Hospital of Chengdu, Chengdu, China
- Hui Zhang
- Sichuan Birth Defects Clinical Research Center, West China Second University Hospital, Sichuan University, Chengdu, China
- Hui Zhang
- Key Laboratory of Chronobiology (Sichuan University), National Health Commission of China, Chengdu, China
- Hui Zhang
- The Joint Laboratory for Lung Development and Related Diseases of West China Second University Hospital, Sichuan University and School of Life Sciences of Fudan University, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu, China
- Qi-Wei Li
- Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China
- Qi-Wei Li
- Sichuan Birth Defects Clinical Research Center, West China Second University Hospital, Sichuan University, Chengdu, China
- Qi-Wei Li
- Key Laboratory of Chronobiology (Sichuan University), National Health Commission of China, Chengdu, China
- Qi-Wei Li
- The Joint Laboratory for Lung Development and Related Diseases of West China Second University Hospital, Sichuan University and School of Life Sciences of Fudan University, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu, China
- Qi-Wei Li
- Department of Pediatric Pulmonology and Immunology, West China Second University Hospital, Sichuan University, Chengdu, China
- Yuan-Yuan Li
- Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China
- Yuan-Yuan Li
- Sichuan Birth Defects Clinical Research Center, West China Second University Hospital, Sichuan University, Chengdu, China
- Yuan-Yuan Li
- Key Laboratory of Chronobiology (Sichuan University), National Health Commission of China, Chengdu, China
- Yuan-Yuan Li
- The Joint Laboratory for Lung Development and Related Diseases of West China Second University Hospital, Sichuan University and School of Life Sciences of Fudan University, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu, China
- Xue Tang
- Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China
- Xue Tang
- Sichuan Birth Defects Clinical Research Center, West China Second University Hospital, Sichuan University, Chengdu, China
- Xue Tang
- Key Laboratory of Chronobiology (Sichuan University), National Health Commission of China, Chengdu, China
- Xue Tang
- The Joint Laboratory for Lung Development and Related Diseases of West China Second University Hospital, Sichuan University and School of Life Sciences of Fudan University, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu, China
- Ling Gu
- Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China
- Ling Gu
- Sichuan Birth Defects Clinical Research Center, West China Second University Hospital, Sichuan University, Chengdu, China
- Ling Gu
- Key Laboratory of Chronobiology (Sichuan University), National Health Commission of China, Chengdu, China
- Ling Gu
- The Joint Laboratory for Lung Development and Related Diseases of West China Second University Hospital, Sichuan University and School of Life Sciences of Fudan University, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu, China
- Han-Min Liu
- Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China
- Han-Min Liu
- Sichuan Birth Defects Clinical Research Center, West China Second University Hospital, Sichuan University, Chengdu, China
- Han-Min Liu
- Key Laboratory of Chronobiology (Sichuan University), National Health Commission of China, Chengdu, China
- Han-Min Liu
- The Joint Laboratory for Lung Development and Related Diseases of West China Second University Hospital, Sichuan University and School of Life Sciences of Fudan University, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu, China
- Han-Min Liu
- Department of Pediatric Pulmonology and Immunology, West China Second University Hospital, Sichuan University, Chengdu, China
- DOI
- https://doi.org/10.3389/fimmu.2023.1189195
- Journal volume & issue
-
Vol. 14
Abstract
Pulmonary hypertension (PH) is a chronic pulmonary vascular disorder characterized by an increase in pulmonary vascular resistance and pulmonary arterial pressure. The detailed molecular mechanisms remain unclear. In recent decades, increasing evidence shows that altered immune microenvironment, comprised of immune cells, mesenchymal cells, extra-cellular matrix and signaling molecules, might induce the development of PH. Myeloid-derived suppressor cells (MDSCs) have been proposed over 30 years, and the functional importance of MDSCs in the immune system is appreciated recently. MDSCs are a heterogeneous group of cells that expand during cancer, chronic inflammation and infection, which have a remarkable ability to suppress T-cell responses and may exacerbate the development of diseases. Thus, targeting MDSCs has become a novel strategy to overcome immune evasion, especially in tumor immunotherapy. Nowadays, severe PH is accepted as a cancer-like disease, and MDSCs are closely related to the development and prognosis of PH. Here, we review the relationship between MDSCs and PH with respect to immune cells, cytokines, chemokines and metabolism, hoping that the key therapeutic targets of MDSCs can be identified in the treatment of PH, especially in severe PH.
Keywords
- myeloid-derived suppressor cells
- pulmonary hypertension
- immune microenvironment
- cancer-like
- cytokines
- chemokines
