Nature Communications (Aug 2019)
Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination
Abstract
In multiple sclerosis (MS), antigen-presenting cells inducing cytotoxic T cell response against mature oligodendrocytes remain to be identified. Here the authors show that oligodendrocyte precursors cross-present antigen taken up from mature oligodendrocytes, and are targeted by cytotoxic T cells in cell culture and in an animal model of MS.