ERJ Open Research (Jul 2022)
Prevalence and burden of chronic cough in China: a national cross-sectional study
- Kewu Huang,
- Xiaoying Gu,
- Ting Yang,
- Jianying Xu,
- Lan Yang,
- Jianping Zhao,
- Xiangyan Zhang,
- Chunxue Bai,
- Jian Kang,
- Pixin Ran,
- Huahao Shen,
- Fuqiang Wen,
- Yahong Chen,
- Tieying Sun,
- Guangliang Shan,
- Yingxiang Lin,
- Sinan Wu,
- Ruiying Wang,
- Zhihong Shi,
- Yongjian Xu,
- Xianwei Ye,
- Yuanlin Song,
- Qiuyue Wang,
- Yumin Zhou,
- Wen Li,
- Liren Ding,
- Chun Wan,
- Wanzhen Yao,
- Yanfei Guo,
- Fei Xiao,
- Yong Lu,
- Xiaoxia Peng,
- Dan Xiao,
- Xiaoning Bu,
- Hong Zhang,
- Xiaolei Zhang,
- Li An,
- Shu Zhang,
- Zhixin Cao,
- Qingyuan Zhan,
- Yuanhua Yang,
- Lirong Liang,
- Huaping Dai,
- Bin Cao,
- Jiang He,
- Kian Fan Chung,
- Chen Wang
Affiliations
- Kewu Huang
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Dept of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
- Xiaoying Gu
- National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Beijing, China
- Ting Yang
- National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Beijing, China
- Jianying Xu
- Dept of Pulmonary and Critical Care Medicine, Shanxi Bethune Hospital, Taiyuan, China
- Lan Yang
- Dept of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
- Jianping Zhao
- Dept of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Xiangyan Zhang
- Dept of Pulmonary and Critical Care Medicine, Guizhou Provincial People's Hospital, Guiyang, China
- Chunxue Bai
- Dept of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China
- Jian Kang
- Dept of Pulmonary and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, China
- Pixin Ran
- State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
- Huahao Shen
- Dept of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China
- Fuqiang Wen
- State Key Laboratory of Biotherapy of China and Dept of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China
- Yahong Chen
- Dept of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, China
- Tieying Sun
- Dept of Respiratory and Critical Care Medicine, Beijing Hospital, Beijing, China
- Guangliang Shan
- Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences; School of Basic Medicine, Peking Union Medical College, Beijing, China
- Yingxiang Lin
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Dept of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
- Sinan Wu
- National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Beijing, China
- Ruiying Wang
- Dept of Pulmonary and Critical Care Medicine, Shanxi Bethune Hospital, Taiyuan, China
- Zhihong Shi
- Dept of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
- Yongjian Xu
- Dept of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Xianwei Ye
- Dept of Pulmonary and Critical Care Medicine, Guizhou Provincial People's Hospital, Guiyang, China
- Yuanlin Song
- Dept of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China
- Qiuyue Wang
- Dept of Pulmonary and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, China
- Yumin Zhou
- State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
- Wen Li
- Dept of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China
- Liren Ding
- Dept of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China
- Chun Wan
- State Key Laboratory of Biotherapy of China and Dept of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China
- Wanzhen Yao
- Dept of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, China
- Yanfei Guo
- Dept of Respiratory and Critical Care Medicine, Beijing Hospital, Beijing, China
- Fei Xiao
- National Center of Gerontology, Beijing Hospital, Beijing, China
- Yong Lu
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Dept of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
- Xiaoxia Peng
- Center for Clinical Epidemiology and Evidence-based Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China
- Dan Xiao
- National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Beijing, China
- Xiaoning Bu
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Dept of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
- Hong Zhang
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Dept of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
- Xiaolei Zhang
- National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Beijing, China
- Li An
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Dept of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
- Shu Zhang
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Dept of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
- Zhixin Cao
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Dept of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
- Qingyuan Zhan
- National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Beijing, China
- Yuanhua Yang
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Dept of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
- Lirong Liang
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Dept of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
- Huaping Dai
- National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Beijing, China
- Bin Cao
- National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Beijing, China
- Jiang He
- Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA
- Kian Fan Chung
- National Heart & Lung Institute, Imperial College London, and Royal Brompton & Harefield NHS Trust, London, UK
- Chen Wang
- National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Beijing, China
- DOI
- https://doi.org/10.1183/23120541.00075-2022
- Journal volume & issue
-
Vol. 8,
no. 3
Abstract
Background Chronic cough is a common complaint, but there are no population-based data on its burden in China. We determined the prevalence of chronic cough and its impact on health status in adults stratified by sex, age and the diagnosis of COPD or the presence of small airway dysfunction (SAD). Methods A representative sample of 57 779 Chinese adults aged 20 years or older was recruited and pulmonary function test was measured. Chronic cough was defined as cough lasting for >3 months in each year. Quality of life was assessed by the 12-item Short Form Health Survey (SF-12), and self-reported history of hospital visits was recorded. Results Chronic cough was found in 3.6% (95% CI 3.1–4.1) of Chinese adults, 2.4% (95% CI 1.9–3.1) of those aged 20–49 years and 6.0% (95% CI 5.3–6.8) of those aged 50 years or older. Individuals with chronic cough had an impaired physical component summary (PCS) score of the SF-12 (p<0.0001) and more emergency visits (p=0.0042) and hospital admissions (p=0.0002). Furthermore, the impact of chronic cough on PCS score was more significant in those aged 50 years or older, or with COPD (p=0.0018 or 0.0002, respectively), with the impact on hospital admission being more significant in those with COPD or with SAD (p=0.0026 or 0.0065, respectively). Conclusions Chronic cough is prevalent in China and is associated with a poorer health status, especially in individuals aged 50 years or older and those with the diagnosis of COPD or SAD.
