The Problem of Anti-Cytokine Therapy in Psoriasis Patients

Abstract

All forms of psoriasis show an increase in the presence of certain cytokines, including, IL-2, IL-6, IL-8 and TNF-alpha, with the last one revealing direct participation in the pathogenesis of dermatosis as modern biological therapeutic agents act directly on the activation of this cytokine. A study of the cytokine profile shows Th1-type immune response in the psoriasis patients, the severity of which depends upon the clinical form of the dermatosis. In this study, 104 patients with psoriasis were treated using the immunomodulating preparation, polyoxidonium, in a complex therapy. In these patients, the regress of the PASI index was noted, which concurred with the normalization of the known parameters of the cytokines, and primarily, with a reduction in the TNF-alpha level, which clearly demonstrated the therapeutic efficacy of polyoxidonium, the preparation used.

Keywords

• psoriasis
• clinical picture
• cytokines
• treatment