Prohormone convertase 1/3 deficiency causes obesity due to impaired proinsulin processing

Daniel T. Meier; Leila Rachid; Sophia J. Wiedemann; Shuyang Traub; Kelly Trimigliozzi; Marc Stawiski; Loïc Sauteur; Denise V. Winter; Christelle Le Foll; Catherine Brégère; Raphael Guzman; Alex Odermatt; Marianne Böni-Schnetzler; Marc Y. Donath

doi:10.1038/s41467-022-32509-4

Nature Communications (Aug 2022)

Prohormone convertase 1/3 deficiency causes obesity due to impaired proinsulin processing

Daniel T. Meier,
Leila Rachid,
Sophia J. Wiedemann,
Shuyang Traub,
Kelly Trimigliozzi,
Marc Stawiski,
Loïc Sauteur,
Denise V. Winter,
Christelle Le Foll,
Catherine Brégère,
Raphael Guzman,
Alex Odermatt,
Marianne Böni-Schnetzler,
Marc Y. Donath

Affiliations

Daniel T. Meier: Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel
Leila Rachid: Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel
Sophia J. Wiedemann: Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel
Shuyang Traub: Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel
Kelly Trimigliozzi: Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel
Marc Stawiski: Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel
Loïc Sauteur: Department of Biomedicine, University of Basel
Denise V. Winter: Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel
Christelle Le Foll: Institute of Veterinary Physiology, University of Zurich
Catherine Brégère: Department of Biomedicine, University of Basel
Raphael Guzman: Department of Biomedicine, University of Basel
Alex Odermatt: Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel
Marianne Böni-Schnetzler: Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel
Marc Y. Donath: Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel

DOI: https://doi.org/10.1038/s41467-022-32509-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

Read online

Defective insulin secretion is observed early in the development of diabetes. Here the authors report that β cell-specific deficiency of the insulin prohormone convertase 1/3 (PC1/3) leads not only to hyperglycemia, but also to hyperphagic obesity in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal