Most mitochondrial dGTP is tightly bound to respiratory complex I through the NDUFA10 subunit

David Molina-Granada; Emiliano González-Vioque; Marris G. Dibley; Raquel Cabrera-Pérez; Antoni Vallbona-Garcia; Javier Torres-Torronteras; Leonid A. Sazanov; Michael T. Ryan; Yolanda Cámara; Ramon Martí

doi:10.1038/s42003-022-03568-6

Communications Biology (Jun 2022)

Most mitochondrial dGTP is tightly bound to respiratory complex I through the NDUFA10 subunit

David Molina-Granada,
Emiliano González-Vioque,
Marris G. Dibley,
Raquel Cabrera-Pérez,
Antoni Vallbona-Garcia,
Javier Torres-Torronteras,
Leonid A. Sazanov,
Michael T. Ryan,
Yolanda Cámara,
Ramon Martí

Affiliations

David Molina-Granada: Research Group on Neuromuscular and Mitochondrial Disorders, Vall d’Hebron Institut de Recerca, Universitat Autònoma de Barcelona
Emiliano González-Vioque: Research Group on Neuromuscular and Mitochondrial Disorders, Vall d’Hebron Institut de Recerca, Universitat Autònoma de Barcelona
Marris G. Dibley: Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University
Raquel Cabrera-Pérez: Research Group on Neuromuscular and Mitochondrial Disorders, Vall d’Hebron Institut de Recerca, Universitat Autònoma de Barcelona
Antoni Vallbona-Garcia: Research Group on Neuromuscular and Mitochondrial Disorders, Vall d’Hebron Institut de Recerca, Universitat Autònoma de Barcelona
Javier Torres-Torronteras: Research Group on Neuromuscular and Mitochondrial Disorders, Vall d’Hebron Institut de Recerca, Universitat Autònoma de Barcelona
Leonid A. Sazanov: Institute of Science and Technology Austria
Michael T. Ryan: Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University
Yolanda Cámara: Research Group on Neuromuscular and Mitochondrial Disorders, Vall d’Hebron Institut de Recerca, Universitat Autònoma de Barcelona
Ramon Martí: Research Group on Neuromuscular and Mitochondrial Disorders, Vall d’Hebron Institut de Recerca, Universitat Autònoma de Barcelona

DOI: https://doi.org/10.1038/s42003-022-03568-6
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 16

Abstract

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Mitochondrial dGTP is mostly bound to an accessory subunit of complex I of the mitochondrial respiratory chain, which may reveal a mechanism linking mitochondrial dNTP availability and oxidative metabolism.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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