ASSOCIATION OF IL-1β, IL-4 AND IL-6 GENES POLYMORPHISMS WITH GENETIC PREDISPOSITION FOR AUTOIMMUNE THYROIDITIS

Abstract

Abstract. Autoimmune thyroiditis (Hashimoto’s thyroiditis, HT) still represents an unresolved problem of modern endocrinology, since its etiology and pathogenesis are yet unclear. Cytokines play an important role in the regulation of immune and inflammatory response, therefore, some gene variants encoding them, are considered as potential risk risk factors for autoimmune thyroid diseases. We have genotyped 298 women from the Republic of Tatarstan (RT, control group, 137 persons; HT patients, 161) for the following gene polymorphisms: interleukin-1 beta (IL-1β) +3953 C/T (rs 1143634); interleukin 4 (IL-4) -590C/T (rs 2243250), and interleukin 6 (IL-6) -174C/G (rs 1800795), using allele-specific PCR. The results showed a significantly increased frequencies of C allele (P = 0.0003) and CT genotype (P = 0.048, OR = 6.05, 95%CI 2.59-2.97) of +3953 C/T of IL-1β in patients with Hashimoto's thyroiditis, as compared with control group. The latter group showed higher prevalence of T allele (P = 0.0003) and TT genotype (P = 4.95 Ч 6.10; OR = 0.15, 95%CI 0.06-0.38). The 590C/T and -174C/G polymorphic variants in, resp., IL-4 and IL-6 genes are not associated with increased risk of this disease among women from RT. (Med. Immunol., 2011, vol. 13, N 6, pp 603-608)

Keywords

• autoimmune thyroiditis
• gene polymorphism
• interleukin 1β
• interleukin 4
• interleukin 6