Genes (Jul 2015)

Relation between ADIPOQ Gene Polymorphisms and Type 2 Diabetes

  • Zhi-Peng Li,
  • Mei Zhang,
  • Jie Gao,
  • Guo-Yan Zhou,
  • Shuang-Qing Li,
  • Zhen-Mei An

DOI
https://doi.org/10.3390/genes6030512
Journal volume & issue
Vol. 6, no. 3
pp. 512 – 519

Abstract

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Objective: The manuscript investigates the relation between adiponectin gene (ADIPOQ) polymorphisms and type 2 diabetes mellitus (T2DM) in a Chinese population. Methods: We designed a case-control study involving 340 normal glucose tolerant (NGT) subjects and 340 type 2 diabetes patients. Three SNPs (rs182052, rs1501299, and rs7627128) were genotyped by TaqMan methods. Results: We found that rs7627128, rs1501299 and rs182052 were significantly associated with T2DM. Haplotypes analysis indicated that the frequency of the haplotypes A-A-T was frequent in T2DM patients (OR = 2.10; 95%CI: 1.44–2.90; p < 0.001), but G-A-T was more frequent in the control group than in the T2DM group (OR = 0.66; 95%CI: 0.54–0.81; p < 0.001). Conclusion: The ADIPOQ genetic polymorphisms were associated with type 2 diabetes in a Chinese population.

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