DIAGNOSTIC AND PROGNOSTIC VALUES OF B-TYPE NATRIURETIC PEPTIDES AND N-TERMINAL FRAGMENT BRAIN NATRIURETIC PEPTIDES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND CHRONIC KIDNEY DISEASE

Abstract

Plasma brain natriuretic peptide (BNP) and N-probrain natriuretic peptide (N-proBNP) levels have been shown to provide valuable prognostic information on short and long-term mortality in patients with chronic heart failure (CHF). We investigated the levels of BNP and N-proBNP in type 2 diabetes (DT2) patients with chronic kidney disease (CKD) in the absence of CHF symptoms. We examined 257 patients with DT2 aged from 23 to 86 years. The levels of BNP and N-proBNP were significantly higher in patients with DT2 as compared to the control group of healthy subjects. There was a significant rise in NT-proBNP and BNP as glomerular filtration rate declined. Our findings indicate the occurrence of N-proBNP and BNP elevation in patients with DT2 and CKD in the absence of CHF symptoms and their interconnections with renal function.

Keywords

• natriuretic peptide
• heart failure
• diabetes mellitus
• chronic kidney disease
• cardiorenal syndrome