Influence of Clinical and Psychosocial Factors on the Acceptance of no Human Organs in Transplants: Xenotransplants

Abstract

Introduction: Xenotransplantation is defined as the transplantation of cells, organs and tissues between different species. It is studied as an alternative method to acquire an adequate supply of human organs, which imbalance in demand results in increased mortality on the transplantation waiting list. The aim of the present study was to deepen knowledge about the psychosocial aspects that influence the acceptance or refusal of xenotransplantation, seeking to add information that contributes to patients’ decisions. Methods: A cross-sectional observational study was carried out on reports of the perception of potential recipients of a liver transplant treated at the referral center of a university hospital. Two groups of patients were selected for thestudy: 50 patients undergoing liver transplantation (transplant group = TxG) and 50 candidates on the waiting list (waiting list group = WLP). All of them were given a questionnaire that addresses the psychosocial aspects that led them to form their opinions about xenotransplantation. To compare the groups, parametric and/or nonparametric tests were used, accordingto the nature of the data, as well as association tests. Results: Among the interviewees, 91 (91%), being 46% in TxG and 45% in WLP believe that xenotransplants would be beneficial for patients on the waiting list and there was no significant difference between the two groups studied (p = 0.8418); 63(63%) stated that religion influenced theiropinions; 74 (74%) stated that their personal experiences, especially in relation to the suffering generated by theirunderlying diseases, influenced the way they answered the questionnaire. Conclusions: The acceptance of xenotransplantation is high among the studied groups, and advanced disease and its complications contribute to the acceptance of this treatment modality, both in patients who have already been transplanted and in those who are on the waiting list. Religion had a positive influence in the acceptance of the xeno-organ. None of the measured social and demographic factors scored a p ≤ 0.05 when correlated as a factor for the decision of accepting a xeno-organ. The low number of patients who rejected this technique claimed that lack of information on the subjectinfluenced in their decision. The results gathered indicate a high acceptance of xenografts among the studied groups, and that dissemination of information about xenografts can contribute to increasedreceptivity to this procedure, furthering its potential as a solution for human organ shortages.

Keywords

• Heterologous transplantation
• Liver transplant
• Graft
• Liver disease
• Histocompatibility