The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells

Roberta Cascella; Serene W. Chen; Alessandra Bigi; José D. Camino; Catherine K. Xu; Christopher M. Dobson; Fabrizio Chiti; Nunilo Cremades; Cristina Cecchi

doi:10.1038/s41467-021-21937-3

Nature Communications (Mar 2021)

The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells

Roberta Cascella,
Serene W. Chen,
Alessandra Bigi,
José D. Camino,
Catherine K. Xu,
Christopher M. Dobson,
Fabrizio Chiti,
Nunilo Cremades,
Cristina Cecchi

Affiliations

Roberta Cascella: Department of Experimental and Clinical Biomedical Sciences, Section of Biochemistry, University of Florence
Serene W. Chen: Department of Life Science, Imperial College London
Alessandra Bigi: Department of Experimental and Clinical Biomedical Sciences, Section of Biochemistry, University of Florence
José D. Camino: Institute for Biocomputation and Physics of Complex Systems (BIFI), Joint Unit BIFI-Institute of Physical Chemistry “Rocasolano” (CSIC), University of Zaragoza
Catherine K. Xu: Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge
Christopher M. Dobson: Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge
Fabrizio Chiti: Department of Experimental and Clinical Biomedical Sciences, Section of Biochemistry, University of Florence
Nunilo Cremades: Institute for Biocomputation and Physics of Complex Systems (BIFI), Joint Unit BIFI-Institute of Physical Chemistry “Rocasolano” (CSIC), University of Zaragoza
Cristina Cecchi: Department of Experimental and Clinical Biomedical Sciences, Section of Biochemistry, University of Florence

DOI: https://doi.org/10.1038/s41467-021-21937-3
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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The self-assembly of α-synuclein (αS) is a pathological feature of Parkinson’s disease. The αS species responsible for neuronal damage are not well characterized. Here, the authors show that αS fibrils release soluble prefibrillar oligomeric species responsible for neurotoxicity in vitro.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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