Nature Communications (Feb 2021)
Mechanochemical control of epidermal stem cell divisions by B-plexins
- Chen Jiang,
- Ahsan Javed,
- Laura Kaiser,
- Michele M. Nava,
- Rui Xu,
- Dominique T. Brandt,
- Dandan Zhao,
- Benjamin Mayer,
- Javier Fernández-Baldovinos,
- Luping Zhou,
- Carsten Höß,
- Kovilen Sawmynaden,
- Arkadiusz Oleksy,
- David Matthews,
- Lee S. Weinstein,
- Heidi Hahn,
- Hermann-Josef Gröne,
- Peter L. Graumann,
- Carien M. Niessen,
- Stefan Offermanns,
- Sara A. Wickström,
- Thomas Worzfeld
Affiliations
- Chen Jiang
- Institute of Pharmacology, University of Marburg
- Ahsan Javed
- Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki
- Laura Kaiser
- Institute of Pharmacology, University of Marburg
- Michele M. Nava
- Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki
- Rui Xu
- Institute of Pharmacology, University of Marburg
- Dominique T. Brandt
- Institute of Pharmacology, University of Marburg
- Dandan Zhao
- Institute of Pharmacology, University of Marburg
- Benjamin Mayer
- Biochemistry, Faculty of Chemistry, and Center for Synthetic Microbiology (synmikro), University of Marburg
- Javier Fernández-Baldovinos
- Institute of Pharmacology, University of Marburg
- Luping Zhou
- Institute of Pharmacology, University of Marburg
- Carsten Höß
- Institute of Pharmacology, University of Marburg
- Kovilen Sawmynaden
- LifeArc
- Arkadiusz Oleksy
- LifeArc
- David Matthews
- LifeArc
- Lee S. Weinstein
- Metabolic Diseases Branch, NIDDK, NIH
- Heidi Hahn
- Institute of Human Genetics, University Medical Center Göttingen
- Hermann-Josef Gröne
- Institute of Pharmacology, University of Marburg
- Peter L. Graumann
- Biochemistry, Faculty of Chemistry, and Center for Synthetic Microbiology (synmikro), University of Marburg
- Carien M. Niessen
- Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne, University of Cologne
- Stefan Offermanns
- Department of Pharmacology, Max-Planck-Institute for Heart and Lung Research
- Sara A. Wickström
- Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki
- Thomas Worzfeld
- Institute of Pharmacology, University of Marburg
- DOI
- https://doi.org/10.1038/s41467-021-21513-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
It is unclear how epithelial tissues adjust cell division rates to cell density. Here, the authors show that Plexin-B1 and Plexin-B2 sense mechanical compression (crowding) of epidermal stem cells, resulting in inactivation of YAP and suppression of cell proliferation.
