Nature Communications (Jul 2019)
Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma
- Malgorzata Czystowska-Kuzmicz,
- Anna Sosnowska,
- Dominika Nowis,
- Kavita Ramji,
- Marta Szajnik,
- Justyna Chlebowska-Tuz,
- Ewa Wolinska,
- Pawel Gaj,
- Magdalena Grazul,
- Zofia Pilch,
- Abdessamad Zerrouqi,
- Agnieszka Graczyk-Jarzynka,
- Karolina Soroczynska,
- Szczepan Cierniak,
- Robert Koktysz,
- Esther Elishaev,
- Slawomir Gruca,
- Artur Stefanowicz,
- Roman Blaszczyk,
- Bartlomiej Borek,
- Anna Gzik,
- Theresa Whiteside,
- Jakub Golab
Affiliations
- Malgorzata Czystowska-Kuzmicz
- Department of Immunology, Medical University of Warsaw
- Anna Sosnowska
- Department of Immunology, Medical University of Warsaw
- Dominika Nowis
- Department of Immunology, Medical University of Warsaw
- Kavita Ramji
- Department of Immunology, Medical University of Warsaw
- Marta Szajnik
- Holy Family Obstetrics and Gynecology Hospital
- Justyna Chlebowska-Tuz
- Laboratory of Experimental Medicine, Center of New Technologies, University of Warsaw
- Ewa Wolinska
- Department of Pathology, Medical University of Warsaw
- Pawel Gaj
- Laboratory of Human Cancer Genetics, Center of New Technologies, University of Warsaw
- Magdalena Grazul
- Department of Immunology, Medical University of Warsaw
- Zofia Pilch
- Department of Immunology, Medical University of Warsaw
- Abdessamad Zerrouqi
- Department of Immunology, Medical University of Warsaw
- Agnieszka Graczyk-Jarzynka
- Department of Immunology, Medical University of Warsaw
- Karolina Soroczynska
- Department of Immunology, Medical University of Warsaw
- Szczepan Cierniak
- Department of Gynecology and Gynecologic Oncology, Military Institute of Medicine
- Robert Koktysz
- Department of Gynecology and Gynecologic Oncology, Military Institute of Medicine
- Esther Elishaev
- Department of Pathology, University of Pittsburgh, School of Medicine
- Slawomir Gruca
- Department of Immunology, Medical University of Warsaw
- Artur Stefanowicz
- Department of Gynecology and Obstetrics, “Praski” Hospital
- Roman Blaszczyk
- OncoArendi Therapeutics
- Bartlomiej Borek
- OncoArendi Therapeutics
- Anna Gzik
- OncoArendi Therapeutics
- Theresa Whiteside
- Department of Pathology, University of Pittsburgh, School of Medicine
- Jakub Golab
- Department of Immunology, Medical University of Warsaw
- DOI
- https://doi.org/10.1038/s41467-019-10979-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Cancer cells employ a variety of ways to escape the immune system. Here, the authors show that ovarian cancer cells produce small extracellular vescicles containing arginase 1 that are taken up by dendritic cells in the draining lymph nodes, resulting in inhibition of antigen-specific T-cell proliferation.
