Nature Communications (Jun 2018)
IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes
- Yukihide Momozawa,
- Julia Dmitrieva,
- Emilie Théâtre,
- Valérie Deffontaine,
- Souad Rahmouni,
- Benoît Charloteaux,
- François Crins,
- Elisa Docampo,
- Mahmoud Elansary,
- Ann-Stephan Gori,
- Christelle Lecut,
- Rob Mariman,
- Myriam Mni,
- Cécile Oury,
- Ilya Altukhov,
- Dmitry Alexeev,
- Yuri Aulchenko,
- Leila Amininejad,
- Gerd Bouma,
- Frank Hoentjen,
- Mark Löwenberg,
- Bas Oldenburg,
- Marieke J. Pierik,
- Andrea E. vander Meulen-de Jong,
- C. Janneke van der Woude,
- Marijn C. Visschedijk,
- The International IBD Genetics Consortium,
- Mark Lathrop,
- Jean-Pierre Hugot,
- Rinse K. Weersma,
- Martine De Vos,
- Denis Franchimont,
- Severine Vermeire,
- Michiaki Kubo,
- Edouard Louis,
- Michel Georges
Affiliations
- Yukihide Momozawa
- Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Liège (B34)
- Julia Dmitrieva
- Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Liège (B34)
- Emilie Théâtre
- Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Liège (B34)
- Valérie Deffontaine
- Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Liège (B34)
- Souad Rahmouni
- Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Liège (B34)
- Benoît Charloteaux
- Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Liège (B34)
- François Crins
- Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Liège (B34)
- Elisa Docampo
- Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Liège (B34)
- Mahmoud Elansary
- Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Liège (B34)
- Ann-Stephan Gori
- Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Liège (B34)
- Christelle Lecut
- Laboratory of Thrombosis and Hemostasis, GIGA-R, University of Liège (B34)
- Rob Mariman
- Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Liège (B34)
- Myriam Mni
- Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Liège (B34)
- Cécile Oury
- Laboratory of Thrombosis and Hemostasis, GIGA-R, University of Liège (B34)
- Ilya Altukhov
- Moscow Institute of Physics and Technology
- Dmitry Alexeev
- Novosibirsk State University
- Yuri Aulchenko
- PolyOmica
- Leila Amininejad
- Gastroentérologie Médicale, Faculté de Médicine, Université Libre de Bruxelles
- Gerd Bouma
- Department of Gastroenterology and Hepatology, VU University Medical Centre
- Frank Hoentjen
- Department of Gastroenterology and Hepatology, University Medical Centre St. Radboud
- Mark Löwenberg
- Department of Gastroenterology and Hepatology, Amsterdam Medical Centre
- Bas Oldenburg
- Department of Gastroenterology and Hepatology, University Medical Centre Utrecht
- Marieke J. Pierik
- Department of Gastroenterology and Hepatology, University Medical Centre Maastricht
- Andrea E. vander Meulen-de Jong
- Department of Gastroenterology and Hepatology, Leiden University Medical Centre
- C. Janneke van der Woude
- Department of Gastroenterology and Hepatology, Erasmus Medical Centre
- Marijn C. Visschedijk
- Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen
- The International IBD Genetics Consortium
- Mark Lathrop
- McGill University Centre for Molecular and Computational Genomics
- Jean-Pierre Hugot
- UMR 1149 INSERM/Université Paris-Diderot Sorbonne Paris-Cité, Assistance Publique Hôpitaux de Paris
- Rinse K. Weersma
- Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen
- Martine De Vos
- Department of Gastroenterology, University Hospital
- Denis Franchimont
- Gastroentérologie Médicale, Faculté de Médicine, Université Libre de Bruxelles
- Severine Vermeire
- Translational Research in Gastrointestinal Disorders, Department of Clinical and Experimental Medicine, KU Leuven
- Michiaki Kubo
- Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Science
- Edouard Louis
- CHU-Liège and Unit of Gastroenterology, GIGA-R & Faculty of Medicine, University of Liège
- Michel Georges
- Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Liège (B34)
- DOI
- https://doi.org/10.1038/s41467-018-04365-8
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 18
Abstract
Most of the more than 200 known genetic risk loci for inflammatory bowel disease (IBD) reside in regulatory regions. Here, the authors provide eQTL datasets for six circulating immune cell types and ileal, colonic and rectal biopsies to map regulatory modules and identify potential causative genes for IBD.
