Nature Communications (Nov 2022)
Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae
- Christine Rother,
- Ruth E. Uhlmann,
- Stephan A. Müller,
- Juliane Schelle,
- Angelos Skodras,
- Ulrike Obermüller,
- Lisa M. Häsler,
- Marius Lambert,
- Frank Baumann,
- Ying Xu,
- Carina Bergmann,
- Giulia Salvadori,
- Maarten Loos,
- Irena Brzak,
- Derya Shimshek,
- Ulf Neumann,
- Dominantly Inherited Alzheimer Network,
- Lary C. Walker,
- Stephanie A. Schultz,
- Jasmeer P. Chhatwal,
- Stephan A. Kaeser,
- Stefan F. Lichtenthaler,
- Matthias Staufenbiel,
- Mathias Jucker
Affiliations
- Christine Rother
- Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen
- Ruth E. Uhlmann
- Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen
- Stephan A. Müller
- German Center for Neurodegenerative Diseases (DZNE)
- Juliane Schelle
- Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen
- Angelos Skodras
- Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen
- Ulrike Obermüller
- Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen
- Lisa M. Häsler
- Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen
- Marius Lambert
- Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen
- Frank Baumann
- Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen
- Ying Xu
- Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen
- Carina Bergmann
- Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen
- Giulia Salvadori
- Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen
- Maarten Loos
- Sylics (Synaptologics BV)
- Irena Brzak
- Novartis Institutes for Biomedical Research
- Derya Shimshek
- Novartis Institutes for Biomedical Research
- Ulf Neumann
- Novartis Institutes for Biomedical Research
- Dominantly Inherited Alzheimer Network
- Lary C. Walker
- Department of Neurology and Emory National Primate Research Center, Emory University
- Stephanie A. Schultz
- Department of Neurology, Massachusetts General Hospital
- Jasmeer P. Chhatwal
- Department of Neurology, Massachusetts General Hospital
- Stephan A. Kaeser
- Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen
- Stefan F. Lichtenthaler
- German Center for Neurodegenerative Diseases (DZNE)
- Matthias Staufenbiel
- Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen
- Mathias Jucker
- Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen
- DOI
- https://doi.org/10.1038/s41467-022-34538-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
The poor correlation between brain Aβ deposition and clinical symptoms in Alzheimer´s disease remains puzzling. Here, the authors show a temporal dissociation of Aβ deposition and neurodegeneration.
