CHMP2A regulates tumor sensitivity to natural killer cell-mediated cytotoxicity

Davide Bernareggi; Qi Xie; Briana C. Prager; Jiyoung Yun; Luisjesus S. Cruz; Timothy V. Pham; William Kim; Xiqing Lee; Michael Coffey; Cristina Zalfa; Pardis Azmoon; Huang Zhu; Pablo Tamayo; Jeremy N. Rich; Dan S. Kaufman

doi:10.1038/s41467-022-29469-0

Nature Communications (Apr 2022)

CHMP2A regulates tumor sensitivity to natural killer cell-mediated cytotoxicity

Davide Bernareggi,
Qi Xie,
Briana C. Prager,
Jiyoung Yun,
Luisjesus S. Cruz,
Timothy V. Pham,
William Kim,
Xiqing Lee,
Michael Coffey,
Cristina Zalfa,
Pardis Azmoon,
Huang Zhu,
Pablo Tamayo,
Jeremy N. Rich,
Dan S. Kaufman

Affiliations

Davide Bernareggi: Department of Medicine, University of California San Diego
Qi Xie: Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University
Briana C. Prager: Department of Medicine, University of California San Diego
Jiyoung Yun: Department of Medicine, University of California San Diego
Luisjesus S. Cruz: Department of Medicine, University of California San Diego
Timothy V. Pham: Center for Novel Therapeutics and Moores Cancer Center, UCSD
William Kim: Center for Novel Therapeutics and Moores Cancer Center, UCSD
Xiqing Lee: Department of Oncology, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital
Michael Coffey: Department of Medicine, University of California San Diego
Cristina Zalfa: Department of Immunology and Microbiology, The Scripps Research Institute
Pardis Azmoon: Department of Pathology, University of California San Diego
Huang Zhu: Department of Medicine, University of California San Diego
Pablo Tamayo: Center for Novel Therapeutics and Moores Cancer Center, UCSD
Jeremy N. Rich: Department of Medicine, University of California San Diego
Dan S. Kaufman: Department of Medicine, University of California San Diego

DOI: https://doi.org/10.1038/s41467-022-29469-0
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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Genetic alteration can render tumor cells resistant to immune cell-mediated killing. Here based on a genome-wide CRISPR screening, the authors show that expression of CHMP2A confers tumor cell resistance to NK cell-mediated cytotoxicity, mechanistically involving CHMP2A-dependent regulation of extracellular vesicle secretion.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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