Ethnic Aspects of Valproic Acid P-Oxidation

Natalia A. Shnayder; Violetta V. Grechkina; Vera V. Trefilova; Mikhail Ya. Kissin; Ekaterina A. Narodova; Marina M. Petrova; Mustafa Al-Zamil; Natalia P. Garganeeva; Regina F. Nasyrova

doi:10.3390/biomedicines12051036

Biomedicines (May 2024)

Ethnic Aspects of Valproic Acid P-Oxidation

Natalia A. Shnayder,
Violetta V. Grechkina,
Vera V. Trefilova,
Mikhail Ya. Kissin,
Ekaterina A. Narodova,
Marina M. Petrova,
Mustafa Al-Zamil,
Natalia P. Garganeeva,
Regina F. Nasyrova

Affiliations

Natalia A. Shnayder: Institute of Personalized Psychiatry and Neurology, Shared Core Facilities, V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology, 192019 Saint Petersburg, Russia
Violetta V. Grechkina: Institute of Personalized Psychiatry and Neurology, Shared Core Facilities, V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology, 192019 Saint Petersburg, Russia
Vera V. Trefilova: Institute of Personalized Psychiatry and Neurology, Shared Core Facilities, V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology, 192019 Saint Petersburg, Russia
Mikhail Ya. Kissin: Department of Psychiatry and Addiction, I.P. Pavlov First St. Petersburg State Medical University, 197022 Saint Petersburg, Russia
Ekaterina A. Narodova: Shared Core Facilities “Molecular and Cell Technologies”, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia
Marina M. Petrova: Shared Core Facilities “Molecular and Cell Technologies”, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia
Mustafa Al-Zamil: Department of Physiotherapy, Faculty of Continuing Medical Education, Peoples’ Friendship University of Russia, 117198 Moscow, Russia
Natalia P. Garganeeva: Department of General Medical Practice and Outpatient Therapy, Siberian State Medical University, 634050 Tomsk, Russia
Regina F. Nasyrova: Institute of Personalized Psychiatry and Neurology, Shared Core Facilities, V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology, 192019 Saint Petersburg, Russia

DOI: https://doi.org/10.3390/biomedicines12051036
Journal volume & issue: Vol. 12, no. 5
p. 1036

Abstract

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The safety of the use of psychotropic drugs, widely used in neurological and psychiatric practice, is an urgent problem in personalized medicine. This narrative review demonstrated the variability in allelic frequencies of low-functioning and non-functional single nucleotide variants in genes encoding key isoenzymes of valproic acid P-oxidation in the liver across different ethnic/racial groups. The sensitivity and specificity of pharmacogenetic testing panels for predicting the rate of metabolism of valproic acid by P-oxidation can be increased by prioritizing the inclusion of the most common risk allele characteristic of a particular population (country).

Published in Biomedicines

ISSN: 2227-9059 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: http://www.mdpi.com/journal/biomedicines

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Abstract

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