Nature Communications (Oct 2022)

Cholesterol-stabilized membrane-active nanopores with anticancer activities

  • Jie Shen,
  • Yongting Gu,
  • Lingjie Ke,
  • Qiuping Zhang,
  • Yin Cao,
  • Yuchao Lin,
  • Zhen Wu,
  • Caisheng Wu,
  • Yuguang Mu,
  • Yun-Long Wu,
  • Changliang Ren,
  • Huaqiang Zeng

DOI
https://doi.org/10.1038/s41467-022-33639-5
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 10

Abstract

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Bacterial cells utilize cholesterol-enhanced pore formation to specifically target eukaryotic cells. Here, the authors present a class of bio-inspired, cholesterol-enhanced nanopores which display anticancer activities in vitro.