Extinct type of human parvovirus B19 persists in tonsillar B cells

Lari Pyöriä; Mari Toppinen; Elina Mäntylä; Lea Hedman; Leena-Maija Aaltonen; Maija Vihinen-Ranta; Taru Ilmarinen; Maria Söderlund-Venermo; Klaus Hedman; Maria F. Perdomo

doi:10.1038/ncomms14930

Nature Communications (Apr 2017)

Extinct type of human parvovirus B19 persists in tonsillar B cells

Lari Pyöriä,
Mari Toppinen,
Elina Mäntylä,
Lea Hedman,
Leena-Maija Aaltonen,
Maija Vihinen-Ranta,
Taru Ilmarinen,
Maria Söderlund-Venermo,
Klaus Hedman,
Maria F. Perdomo

Affiliations

Lari Pyöriä: Department of Virology, University of Helsinki
Mari Toppinen: Department of Virology, University of Helsinki
Elina Mäntylä: Department of Biological and Environmental Science, and Nanoscience Center, University of Jyväskylä
Lea Hedman: Department of Virology, University of Helsinki
Leena-Maija Aaltonen: Department of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital
Maija Vihinen-Ranta: Department of Biological and Environmental Science, and Nanoscience Center, University of Jyväskylä
Taru Ilmarinen: Department of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital
Maria Söderlund-Venermo: Department of Virology, University of Helsinki
Klaus Hedman: Department of Virology, University of Helsinki
Maria F. Perdomo: Department of Virology, University of Helsinki

DOI: https://doi.org/10.1038/ncomms14930
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 9

Abstract

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The cell type that hosts parvovirus B19 (B19V) DNA lifelong is currently unknown. Here, the authors identify tonsillar B cells as a reservoir, detect an extinct B19V type in older adults, supporting a long-term association, and show that B19V uptake into B cells is antibody dependent.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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