Interaction of antimicrobial peptide with mycolyl transferase in Mycobacterium tuberculosis

Abstract

It is estimated that about 40% of the Indian population are infected with tuberculosis (TB) and that ~3,000,000 people die as a result of TB annually. TB is caused by Mycobacterium tuberculosis. In 2011, the World Health Organization declared India as having the highest TB burden worldwide. An important criteria for pathogenicity is the presence of mycolic acid linked to the protective outer membrane of bacteria. Mycolyl transferase catalyzes the transfer of mycolic acid and promotes cell wall synthesis. This is also considered as a novel target for drug-mediated intervention strategies. Here, we have attempted to understand the interaction between the antimicrobial peptide (AMP), dermcidin, and mycolyl transferase in M. tuberculosis using a computational approach. The present study was undertaken in order to elucidate the capability of AMPs to treat this bacteria, which is less sensitive to available antibiotics, and to design a novel method for new therapies.

Keywords

• Antimicrobial peptides
• Dermcidin
• Mycobacterium tuberculosis
• Mycolyl transferase