Nature Communications (Feb 2020)
AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy
- Marc Dohmen,
- Sarah Krieg,
- Georgios Agalaridis,
- Xiaoqing Zhu,
- Saifeldin N. Shehata,
- Elisabeth Pfeiffenberger,
- Jan Amelang,
- Mareike Bütepage,
- Elena Buerova,
- Carolina M. Pfaff,
- Dipanjan Chanda,
- Stephan Geley,
- Christian Preisinger,
- Kei Sakamoto,
- Bernhard Lüscher,
- Dietbert Neumann,
- Jörg Vervoorts
Affiliations
- Marc Dohmen
- Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University
- Sarah Krieg
- Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University
- Georgios Agalaridis
- Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University
- Xiaoqing Zhu
- CARIM School for Cardiovascular Diseases, Maastricht University
- Saifeldin N. Shehata
- Nestlé Research
- Elisabeth Pfeiffenberger
- Division of Molecular Pathophysiology, Biocenter, Innsbruck Medical University
- Jan Amelang
- Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University
- Mareike Bütepage
- Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University
- Elena Buerova
- Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University
- Carolina M. Pfaff
- Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University
- Dipanjan Chanda
- CARIM School for Cardiovascular Diseases, Maastricht University
- Stephan Geley
- Division of Molecular Pathophysiology, Biocenter, Innsbruck Medical University
- Christian Preisinger
- Proteomics Facility, Interdisciplinary Center for Clinical Research (IZKF) Aachen, Medical School, RWTH Aachen University
- Kei Sakamoto
- Nestlé Research
- Bernhard Lüscher
- Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University
- Dietbert Neumann
- CARIM School for Cardiovascular Diseases, Maastricht University
- Jörg Vervoorts
- Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University
- DOI
- https://doi.org/10.1038/s41467-020-14812-0
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
AMPK integrates information about a cell’s energy status to inform decisions about cellular processes, including autophagy. Here the authors identify cyclin Y as an AMPK substrate, which phosphorylates cyclin Y and promotes its interaction with CDK16 to stimulate autophagy.
