The Effect of Vitamin D Deficiency on Overgrowth of Uterine Fibroids: A Blinded Randomized Clinical Tria

Abstract

Background: To evaluate the effects of vitamin D (vitD) supplement on uterine fibroid growth.Materials and Methods: A randomized blinded clinical trial was conducted at a tertiary university-based hospitalfrom August 2017 to September 2018. Totally, 204 women were enrolled into the study. They had at least one uterinefibroid >10 mm on transvaginal ultrasound and their vitD level was insufficient (i.e. 20-30 ng/ml). The interventiongroup was treated with vitD 50000 U supplements for two months. After 2 months, ultrasound screening and vitDlevel measurement was done in both groups.Results: At first, the mean serum vitD levels in intervention and control group were 23.62 and 23.20 ng/ml, respectively.After 8 weeks, the mean serum vitD levels in the control and intervention group were 22.72 and 28.56 ng/mlrespectively (p <0.05). Also, mean fibroma diameter in the intervention group before and after 8 weeks of vitD supplementationwas 43 ± 4.68 and 42.6 ± 1.31 mm, respectively. Mean uterine fibroid diameter in the control group whichdid not receive vitD supplements, before and after 8 weeks was 41.98 ± 5.25 and 47.81 ± 3.42 mm, respectively. Thevariation in the mean size of the uterine fibroid between the control and intervention group which was respectivelyabout 5.83 mm increase and 0.48 mm decrease, was significant (p <0.001).Conclusion: Our results showed that vitD supplementation prevents fibroid growth. It seems that vitD supplementis a simple, safe and inexpensive modality for leiomyoma growth prevention (Registration number:IRCT201703122576N15).

Keywords

• cell proliferation
• dietary supplements
• leiomyoma
• premenopausal women
• vitamin d