Cytotoxic and apoptotic effect of nanoclinoptilolite on canine osteosarcoma cell lines

Abstract

Clinoptilolite has antiviral, antibacterial, anti-inflammatory, antidiabetic, and anticancer properties due to its biological activities. In various cancer cell culture studies, it has been reported effective against tumour cells and gave positive results in treatment of various tumours in dogs. No study was found on the effects of the nanoparticulate form, nanoclinoptilolite, on cancer cells. The aim of this study was to determine its cytotoxic and apoptotic effects in canine osteosarcoma (OSA) cell culture.

Keywords

• nanoclinoptilolite
• canine osteosarcoma cell line
• apoptosis
• caspase-3 and -7
• bax and bcl2 expression