Siriraj Medical Journal (Mar 2009)
Non-HDL-Cholesterol and Total Cholesterol to HDL-C Ratio in Abdominally Obese Adults in Phitsanulok
Abstract
Objective: To compare non-HDLc and the TC/HDLc ratio in men and women with and without abdominal obesity (AO). To evaluate the association of non-HDLc and the TC/HDLc ratio with the other risk factors and to estimate the non-HDLc and TC/HDLc ratio level in both men and women with AO to establish the cutoff point by using ROC curve analysis. Methods: Data (n=533) was used from adult Phitsanulok participants (aged ≥40 years) who came for their health check ups in the service project. AO was defined as waist circumference (WC) of ≥90 cm for men and ≥80 cm for women. The ttest was used to compare the difference in non-HDLc and the TC/HDLc ratio and other risk factors. The Pearson bi-variate correlation analysis was used to quantify the association of non-HDLc and the TC/HDLc ratio with blood pressure (BP) and other lipids. Results: Both non-HDLc and the TC/HDLc ratio levels were elevated in men and women with AO. However in men neither two variables were significantly different, both non-HDLc and TC/HDLc ratio levels were elevated in men with and without AO. Non-HDLc and the TC/HDLc ratio were significantly higher in women with AO than without AO. We used the ROC curve to estimate cutoff values for non-HDLc and TC/HDLc ratio levels and also other lipids in our Thai subjects. The area under the curve of ROC of triglycerides may be superior to other risk markers for men and women in the present study. Conclusion: Both non-HDLc and the TC/HDLc ratio were elevated in men and women with AO. WC and BP may be better associated markers for non-HDLc and the TC/HDLc ratio for men participants. The combination of elevated non- HDLc, the TC/HDLc ratio, BP, and WC may identifiy a group of participants with more marked risk of CVD, metabolic syndrome, and type 2 diabetes.
