Direct Whole-Genome Sequencing of Cutaneous Strains of Haemophilus ducreyi

Abstract

Haemophilus ducreyi, which causes chancroid, has emerged as a cause of pediatric skin disease. Isolation of H. ducreyi in low-income settings is challenging, limiting phylogenetic investigation. Next-generation sequencing demonstrates that cutaneous strains arise from class I and II H. ducreyi clades and that class II may represent a distinct subspecies.

Keywords

• Whole-genome sequencing
• 16S rRNA gene sequencing
• next-generation sequencing
• yaws
• chancroid
• Haemophilus ducreyi