Nature Communications (Apr 2021)
The impact of non-additive genetic associations on age-related complex diseases
- Marta Guindo-Martínez,
- Ramon Amela,
- Silvia Bonàs-Guarch,
- Montserrat Puiggròs,
- Cecilia Salvoro,
- Irene Miguel-Escalada,
- Caitlin E. Carey,
- Joanne B. Cole,
- Sina Rüeger,
- Elizabeth Atkinson,
- Aaron Leong,
- Friman Sanchez,
- Cristian Ramon-Cortes,
- Jorge Ejarque,
- Duncan S. Palmer,
- Mitja Kurki,
- FinnGen Consortium,
- Krishna Aragam,
- Jose C. Florez,
- Rosa M. Badia,
- Josep M. Mercader,
- David Torrents
Affiliations
- Marta Guindo-Martínez
- Barcelona Supercomputing Center (BSC)
- Ramon Amela
- Barcelona Supercomputing Center (BSC)
- Silvia Bonàs-Guarch
- Barcelona Supercomputing Center (BSC)
- Montserrat Puiggròs
- Barcelona Supercomputing Center (BSC)
- Cecilia Salvoro
- Barcelona Supercomputing Center (BSC)
- Irene Miguel-Escalada
- Barcelona Supercomputing Center (BSC)
- Caitlin E. Carey
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
- Joanne B. Cole
- Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard
- Sina Rüeger
- Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki
- Elizabeth Atkinson
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
- Aaron Leong
- Harvard Medical School
- Friman Sanchez
- Barcelona Supercomputing Center (BSC)
- Cristian Ramon-Cortes
- Barcelona Supercomputing Center (BSC)
- Jorge Ejarque
- Barcelona Supercomputing Center (BSC)
- Duncan S. Palmer
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
- Mitja Kurki
- Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki
- FinnGen Consortium
- Krishna Aragam
- Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
- Jose C. Florez
- Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard
- Rosa M. Badia
- Barcelona Supercomputing Center (BSC)
- Josep M. Mercader
- Barcelona Supercomputing Center (BSC)
- David Torrents
- Barcelona Supercomputing Center (BSC)
- DOI
- https://doi.org/10.1038/s41467-021-21952-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Most genome-wide association studies assume an additive model, exclude the X chromosome, and use one reference panel. Here, the authors implement a strategy including non-additive models and find that the number of loci for age-related traits increases as compared to the additive model alone.
