HCV medication affected by Genetic Variations in Host factors

Abstract

Although standard treatments are nearly life-saving in hepatitis C patients, all patients equally don’t respond to such medications. To achieve a favorable therapeutic response in all patients, medications might alter between individuals based on genetic factor variations. Hence, having a detailed knowledge of the affecting factors on the disease promotion could help us to organize an appropriate regime to treat the HCV patients. The data was collected from the clinical and molecular studies published during the last 15 years that elicited from electronic databases such as Pubmed, Google scholar, Medline, Scopus and web of sciences. The literature reviews the recent clinical studies with the genetic-based aspects, especially those factors affecting on the etiopathological and histological feature of hepatitis C, diagnostic, genetic and viral affecting criteria as well as some effective treatment strategies.

Keywords

• Hepatitis C virus
• Genetic Host Factors
• Sustained Virologic Response