Deciphering genetic causes for sex differences in human health through drug metabolism and transporter genes

Yingbo Huang; Yuting Shan; Weijie Zhang; Adam M. Lee; Feng Li; Barbara E. Stranger; R. Stephanie Huang

doi:10.1038/s41467-023-35808-6

Nature Communications (Jan 2023)

Deciphering genetic causes for sex differences in human health through drug metabolism and transporter genes

Yingbo Huang,
Yuting Shan,
Weijie Zhang,
Adam M. Lee,
Feng Li,
Barbara E. Stranger,
R. Stephanie Huang

Affiliations

Yingbo Huang: Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota
Yuting Shan: Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota
Weijie Zhang: Department of Bioinformatics and Computational Biology, University of Minnesota
Adam M. Lee: Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota
Feng Li: Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota
Barbara E. Stranger: Department of Pharmacology, Center for Genetic Medicine, Northwestern University Feinberg School of Medicine
R. Stephanie Huang: Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota

DOI: https://doi.org/10.1038/s41467-023-35808-6
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 15

Abstract

Read online

Little is known about the causes of sex differences in disease prevalence and treatment outcomes. Here, the authors study the interaction between drug metabolism enzymes and transporters genes and sex in complex human traits to uncover sex differences in the genetic regulation of gene expression, serum biomarkers, and metabolism of drugs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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